Linked Life Data

186696

Source:http://linkedlifedata.com/resource/pubmed/id/186696

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1977-1-28
pubmed:abstractText
Gentamicin is very widely accepted as the most effective antibiotic for treatment of a number of serious Gram-negative infections, but one disadvantage associated with its use is the risk of toxicity particularly affecting the eighth nerve. An account is given of eight years' experience with this antibiotic in which obvious ototoxicity was avoided in hospitalized patients in whom gentamicin treatment was monitored by assay of the residual amounts of antibiotic present in the serum. The relationship between accumulation of gentamicin in patients with renal impairment and ototoxicity is discussed. Attention is drawn also to the presence of an increased risk of ototoxicity in patients, particularly the elderly, in whom mild-to-moderate degrees of renal impairment may be overlooked. In such patients modification of the frequency of the dose of gentamicin is necessary and a schedule of treatment based on the results of assay of residual serum levels of gentamicin is given.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0025-729X
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
481-4
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Treatment with gentamicin monitored by serum antibiotic assay.
pubmed:publicationType
Journal Article