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rdf:type |
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lifeskim:mentions |
umls-concept:C0002085,
umls-concept:C0003595,
umls-concept:C0019699,
umls-concept:C0019704,
umls-concept:C0024002,
umls-concept:C0025260,
umls-concept:C0205178,
umls-concept:C0442027,
umls-concept:C0597198,
umls-concept:C0681850,
umls-concept:C0805586,
umls-concept:C1442488,
umls-concept:C1550501,
umls-concept:C1705241,
umls-concept:C1705242,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
1
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pubmed:dateCreated |
2008-10-20
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pubmed:abstractText |
The APOE epsilon4 allele, an established genetic risk factor for late-onset Alzheimer's disease, has been linked to an increased risk for dementia especially in older individuals with HIV-1 infection. This allele has also been associated with increased memory impairment following oral lorazepam challenge in healthy elderly. Lorazepam and other benzodiazepines are widely prescribed in individuals with HIV-1 infection who are at increased risk for cognitive impairment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0033-3158
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-35
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pubmed:meshHeading |
pubmed-meshheading:18668226-Administration, Oral,
pubmed-meshheading:18668226-Adult,
pubmed-meshheading:18668226-Aged,
pubmed-meshheading:18668226-Alleles,
pubmed-meshheading:18668226-Apolipoprotein E4,
pubmed-meshheading:18668226-Central Nervous System Agents,
pubmed-meshheading:18668226-Dose-Response Relationship, Drug,
pubmed-meshheading:18668226-Double-Blind Method,
pubmed-meshheading:18668226-Female,
pubmed-meshheading:18668226-HIV Seropositivity,
pubmed-meshheading:18668226-Humans,
pubmed-meshheading:18668226-Language Tests,
pubmed-meshheading:18668226-Lorazepam,
pubmed-meshheading:18668226-Male,
pubmed-meshheading:18668226-Mental Recall,
pubmed-meshheading:18668226-Middle Aged,
pubmed-meshheading:18668226-Plasma,
pubmed-meshheading:18668226-Psychomotor Performance,
pubmed-meshheading:18668226-Risk Factors,
pubmed-meshheading:18668226-Verbal Learning
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pubmed:year |
2008
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pubmed:articleTitle |
The apolipoprotein E epsilon4 allele and memory performance in HIV-1 seropositive subjects: differences at baseline but not after acute oral lorazepam challenge.
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pubmed:affiliation |
Geriatric Psychiatry Program, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. pomara@nki.rfmh.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, N.I.H., Extramural
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