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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-7-31
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pubmed:abstractText |
Bendigoles A approximately C are the first secondary metabolites to be isolated from a member of the actinomycete genus Gordonia. They were detected in a culture filtrate extract of Gordonia australis Acta 2299 by HPLC-diode array analysis and characterized as new steroids by mass spectrometry and NMR experiments. Bendigole C show binding affinity to the human progesterone and A approximately C to androgen receptor but are inactive at mineralocorticoid and estrogen receptors. In in vitro transactivation studies bendigoles A and C showed moderate and weak androgenic activities.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
356-64
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18667783-Androgens,
pubmed-meshheading:18667783-Chromatography, High Pressure Liquid,
pubmed-meshheading:18667783-Crystallography, X-Ray,
pubmed-meshheading:18667783-Fermentation,
pubmed-meshheading:18667783-Gordonia Bacterium,
pubmed-meshheading:18667783-Humans,
pubmed-meshheading:18667783-Hydroxysteroids,
pubmed-meshheading:18667783-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18667783-Mass Spectrometry,
pubmed-meshheading:18667783-Molecular Structure,
pubmed-meshheading:18667783-Progesterone,
pubmed-meshheading:18667783-Receptors, Androgen,
pubmed-meshheading:18667783-Receptors, Estrogen,
pubmed-meshheading:18667783-Receptors, Mineralocorticoid
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pubmed:year |
2008
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pubmed:articleTitle |
Bendigoles A approximately C, new steroids from Gordonia australis Acta 2299.
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pubmed:affiliation |
Institut für Chemie, Technische Universität Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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