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rdf:type |
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lifeskim:mentions |
umls-concept:C0005767,
umls-concept:C0019196,
umls-concept:C0022702,
umls-concept:C0023884,
umls-concept:C0042769,
umls-concept:C0085358,
umls-concept:C0181868,
umls-concept:C0220847,
umls-concept:C0400914,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
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pubmed:issue |
19
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pubmed:dateCreated |
2008-9-17
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pubmed:abstractText |
Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-10592667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-10790425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-10802716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-10895429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-11391537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-11435586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-11714747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-12441396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-12441397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-12663785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-12810686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-1385523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-14722311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-15738952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-16236125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-16462801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-16729320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-17239482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-2493728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667501-7475549
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1098-5514
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9782-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18667501-Acute Disease,
pubmed-meshheading:18667501-Animals,
pubmed-meshheading:18667501-CD4-Positive T-Lymphocytes,
pubmed-meshheading:18667501-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18667501-Hepacivirus,
pubmed-meshheading:18667501-Hepatitis C, Chronic,
pubmed-meshheading:18667501-Humans,
pubmed-meshheading:18667501-Immunologic Memory,
pubmed-meshheading:18667501-Interferon-gamma,
pubmed-meshheading:18667501-Kinetics,
pubmed-meshheading:18667501-Liver,
pubmed-meshheading:18667501-Pan troglodytes,
pubmed-meshheading:18667501-RNA, Messenger,
pubmed-meshheading:18667501-T-Lymphocytes,
pubmed-meshheading:18667501-Viral Vaccines
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pubmed:year |
2008
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pubmed:articleTitle |
The kinetics of hepatitis C virus-specific CD8 T-cell responses in the blood mirror those in the liver in acute hepatitis C virus infection.
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pubmed:affiliation |
Immunology Section, LDB, NIDDK, NIH, Bethesda, MD 20892-1800, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Intramural
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