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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells. However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4655-7
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pubmed:meshHeading |
pubmed-meshheading:18667313-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:18667313-Antineoplastic Agents,
pubmed-meshheading:18667313-Cell Line, Tumor,
pubmed-meshheading:18667313-Cell Proliferation,
pubmed-meshheading:18667313-Chemistry, Pharmaceutical,
pubmed-meshheading:18667313-Cyclooxygenase 1,
pubmed-meshheading:18667313-Cyclooxygenase 2,
pubmed-meshheading:18667313-Cyclooxygenase Inhibitors,
pubmed-meshheading:18667313-Drug Design,
pubmed-meshheading:18667313-Humans,
pubmed-meshheading:18667313-Inhibitory Concentration 50,
pubmed-meshheading:18667313-Male,
pubmed-meshheading:18667313-Models, Chemical,
pubmed-meshheading:18667313-Nitric Oxide,
pubmed-meshheading:18667313-Prostatic Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines.
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pubmed:affiliation |
Université de Lille 2, 3 rue du Professeur Laguesse, BP 83, 59006 Lille Cedex, France.
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pubmed:publicationType |
Journal Article
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