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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2008-11-10
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pubmed:abstractText |
Irreversible HER/erbB inhibitors selectively inhibit HER-family kinases by targeting a unique cysteine residue located within the ATP-binding pocket. Sequence alignment reveals that this rare cysteine is also present in ten other protein kinases including all five Tec-family members. We demonstrate that the Tec-family kinase Bmx is potently inhibited by irreversible modification at Cys496 by clinical stage EGFR inhibitors such as CI-1033. This cross-reactivity may have significant clinical implications.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-12370298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-15897464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-15919995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-16046538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-16110019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-16302797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-16492761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-17154430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-17318210,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-17823122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-7690139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-9520419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18667312-9751783
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bmx protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/CI1033,
http://linkedlifedata.com/resource/pubmed/chemical/Cysteine,
http://linkedlifedata.com/resource/pubmed/chemical/Morpholines,
http://linkedlifedata.com/resource/pubmed/chemical/PD168393,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Quinazolines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Tec protein-tyrosine kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BalkSteven PSP,
pubmed-author:DidonatoMichaelM,
pubmed-author:FlatauerLauraL,
pubmed-author:GrayNathanael SNS,
pubmed-author:HurWooyoungW,
pubmed-author:JiangXinnongX,
pubmed-author:KimSungjoonS,
pubmed-author:LarsonBradB,
pubmed-author:MasonDaniel EDE,
pubmed-author:NagleAdvaitA,
pubmed-author:PetersEric CEC,
pubmed-author:SuzukiMelissaM,
pubmed-author:ValenteDavidD,
pubmed-author:VelentzaAnastasiaA,
pubmed-author:WarmuthMarkusM,
pubmed-author:ZagorskaAnnaA,
pubmed-author:ZhangJianmingJ
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5916-9
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pubmed:dateRevised |
2011-4-18
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pubmed:meshHeading |
pubmed-meshheading:18667312-Animals,
pubmed-meshheading:18667312-Cysteine,
pubmed-meshheading:18667312-Mice,
pubmed-meshheading:18667312-Molecular Structure,
pubmed-meshheading:18667312-Morpholines,
pubmed-meshheading:18667312-Protein-Tyrosine Kinases,
pubmed-meshheading:18667312-Quinazolines,
pubmed-meshheading:18667312-Receptor, Epidermal Growth Factor,
pubmed-meshheading:18667312-Sequence Homology, Amino Acid
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pubmed:year |
2008
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pubmed:articleTitle |
Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.
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pubmed:affiliation |
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article
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