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18667310
Source:
http://linkedlifedata.com/resource/pubmed/id/18667310
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0013058
,
umls-concept:C0031336
,
umls-concept:C0041917
,
umls-concept:C0184511
,
umls-concept:C0243072
,
umls-concept:C0871161
,
umls-concept:C1553890
,
umls-concept:C2266861
pubmed:issue
16
pubmed:dateCreated
2008-8-11
pubmed:abstractText
A novel series of potent zwitterionic uracil GnRH antagonists were discovered that showed reduced liability for CYP3A4 enzyme inhibition.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/CYP3A4 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP3A
,
http://linkedlifedata.com/resource/pubmed/chemical/Gonadotropin-Releasing Hormone
,
http://linkedlifedata.com/resource/pubmed/chemical/Ions
,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LHRH
,
http://linkedlifedata.com/resource/pubmed/chemical/Uracil
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1464-3405
pubmed:author
pubmed-author:BetzSteve FSF
,
pubmed-author:BrownMichael SMS
,
pubmed-author:ChenMiM
,
pubmed-author:ChenYongshengY
,
pubmed-author:CoonTimothyT
,
pubmed-author:GuoZhiqiangZ
,
pubmed-author:HuangCharles QCQ
,
pubmed-author:JiangWanlongW
,
pubmed-author:MadanAjayA
,
pubmed-author:ReganColin FCF
,
pubmed-author:RueterJaimie KJK
,
pubmed-author:SaundersJohnJ
,
pubmed-author:StruthersR ScottRS
,
pubmed-author:WenJennyJ
,
pubmed-author:XXX
,
pubmed-author:YangChunC
,
pubmed-author:ZhuYun-FeiYF
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4503-7
pubmed:meshHeading
pubmed-meshheading:18667310-Chemistry, Pharmaceutical
,
pubmed-meshheading:18667310-Cytochrome P-450 CYP3A
,
pubmed-meshheading:18667310-Drug Design
,
pubmed-meshheading:18667310-Gonadotropin-Releasing Hormone
,
pubmed-meshheading:18667310-Humans
,
pubmed-meshheading:18667310-Ions
,
pubmed-meshheading:18667310-Kinetics
,
pubmed-meshheading:18667310-Models, Chemical
,
pubmed-meshheading:18667310-Molecular Structure
,
pubmed-meshheading:18667310-Peptides
,
pubmed-meshheading:18667310-Receptors, LHRH
,
pubmed-meshheading:18667310-Stereoisomerism
,
pubmed-meshheading:18667310-Structure-Activity Relationship
,
pubmed-meshheading:18667310-Uracil
pubmed:year
2008
pubmed:articleTitle
Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.
pubmed:affiliation
Department of Medicinal Chemistry, Neurocrine Biosciences, Inc., 12780 El Camino Real, San Diego, CA 92130, USA.
pubmed:publicationType
Journal Article