Linked Life Data

1866599

Source:http://linkedlifedata.com/resource/pubmed/id/1866599

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-9-10
pubmed:abstractText
Expression of HLA class I antigens on the cell surface requires the association of heavy chain, endogenous peptide and beta 2-microglobulin (beta 2m). We have studied the expression of free class I heavy chain and beta 2m in cryostatic sections of 51 HLA class I negative human tumours of different origin. Selective low expression of beta 2m was observed only on the 9 colorectal adenocarcinomas. In contrast, simultaneous under-expression of heavy chain and beta 2m was detected in the rest of the tumours studied. Our results suggest that the accumulation in the cytoplasm of HLA heavy chain in HLA negative colorectal carcinomas is a particular mechanism that cannot be applied to all HLA negative tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Loss of HLA heavy chain and beta 2-microglobulin in HLA negative tumours.
pubmed:affiliation
Servicio de Análisis Clínicos e Inmunología, Hospital Virgen de las Nieves, Granada, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't