|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2008-8-22
|
|
pubmed:abstractText |
Calcitonin gene-related peptide (CGRP) has been implicated in the pathogenesis of migraine. Early chemistry leads suffered from modest potency, significant CYP3A4 inhibition, and poor aqueous solubility. Herein, we describe the optimization of these leads to give 4 (BMS-694153), a molecule with outstanding potency, a favorable predictive toxicology profile, and remarkable aqueous solubility. Compound 4 has good intranasal bioavailability in rabbits and shows dose-dependent activity in validated in vivo and ex vivo migraine models.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1520-4804
|
|
pubmed:author |
pubmed-author:ChaturvedulaPrasad VPV,
pubmed-author:ConwayCharles MCM,
pubmed-author:CookDeborah ADA,
pubmed-author:DavisCarl DCD,
pubmed-author:DegnanAndrew PAP,
pubmed-author:DentonRexR,
pubmed-author:DubowchikGene MGM,
pubmed-author:HanXiaojunX,
pubmed-author:JD WDW,
pubmed-author:MacciRobertR,
pubmed-author:MacorJohn EJE,
pubmed-author:MathiasNeil RNR,
pubmed-author:MoenchPaulP,
pubmed-author:PinSokhom SSS,
pubmed-author:RenShelly XSX,
pubmed-author:SchartmanRichardR,
pubmed-author:SignorLaura JLJ,
pubmed-author:ThalodyGeorgeG,
pubmed-author:WidmannKimberly AKA
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
28
|
|
pubmed:volume |
51
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4858-61
|
|
pubmed:meshHeading |
pubmed-meshheading:18665579-Administration, Intranasal,
pubmed-meshheading:18665579-Animals,
pubmed-meshheading:18665579-Biological Availability,
pubmed-meshheading:18665579-Calcitonin Gene-Related Peptide,
pubmed-meshheading:18665579-Callithrix,
pubmed-meshheading:18665579-Coronary Vessels,
pubmed-meshheading:18665579-Face,
pubmed-meshheading:18665579-Humans,
pubmed-meshheading:18665579-Indazoles,
pubmed-meshheading:18665579-Migraine Disorders,
pubmed-meshheading:18665579-Quinazolinones,
pubmed-meshheading:18665579-Rabbits,
pubmed-meshheading:18665579-Receptors, Calcitonin Gene-Related Peptide,
pubmed-meshheading:18665579-Regional Blood Flow,
pubmed-meshheading:18665579-Vasodilation
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-carboxamide (BMS-694153): a potent antagonist of the human calcitonin gene-related peptide receptor for migraine with rapid and efficient intranasal exposure.
|
|
pubmed:affiliation |
Department of Neuroscience Chemistry, Bristol-Myers Squibb Research & Development,Wallingford, Connecticut 06492, USA. andrew.degnan@bms.com
|
|
pubmed:publicationType |
Journal Article
|
