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rdf:type |
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lifeskim:mentions |
umls-concept:C0019904,
umls-concept:C0027651,
umls-concept:C0027819,
umls-concept:C0205225,
umls-concept:C0524869,
umls-concept:C0525037,
umls-concept:C0868928,
umls-concept:C0936012,
umls-concept:C1442161,
umls-concept:C1510941,
umls-concept:C1511790,
umls-concept:C1517378,
umls-concept:C1521871,
umls-concept:C1707513
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pubmed:dateCreated |
2008-9-1
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pubmed:abstractText |
Neuroblastoma is a very heterogeneous pediatric tumor of the sympathetic nervous system showing clinically significant patterns of genetic alterations. Favorable tumors usually have near-triploid karyotypes with few structural rearrangements. Aggressive stage 4 tumors often have near-diploid or near-tetraploid karyotypes and structural rearrangements. Whole genome approaches for analysis of genome-wide copy number have been used to analyze chromosomal abnormalities in tumor samples. We have used array-based copy number analysis using oligonucleotide single nucleotide polymorphisms (SNP) arrays to analyze the chromosomal structure of a large number of neuroblastoma tumors of different clinical and biological subsets.
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pubmed:commentsCorrections |
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18664255-922665
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2164
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353
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