Source:http://linkedlifedata.com/resource/pubmed/id/18663996
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-7-30
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pubmed:abstractText |
The main goal of this study was to compare the expression of Zinc-alpha2-glycoprotein (ZAG), a recently described adipokine, in obese and lean subjects. ZAG expression was determined by Real-time PCR analysis in subcutaneous abdominal adipose tissue of eighteen young men, 9 lean (BMI = 23.1 +/- 0.4 kg/m2) and 9 obese (34.7 +/- 1.2 kg/m2) with a similar habitual dietary intake of fat and physical activity, which were assessed by validated methods. Our data revealed that ZAG gene was downregulated (-70%; p < 0.05) in subcutaneous adipose tissue of obese compared to lean subjects. Moreover, statistically significant positive correlations between ZAG gene expression and serum adiponectin (r = 0.89; p < 0.01) and a negative correlation with the plasma levels of leptin (r = -0.82; p < 0.05) and waist circumference (r = -0.64; p < 0.05) were found in obese subjects. Our data suggest that this novel adipokine could play a role in human susceptibility to obesity related disorders and that upregulation of ZAG could be a promising therapeutic target for metabolic syndrome treatment.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1138-7548
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-6
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pubmed:meshHeading |
pubmed-meshheading:18663996-Abdominal Fat,
pubmed-meshheading:18663996-Adipokines,
pubmed-meshheading:18663996-Adult,
pubmed-meshheading:18663996-Body Weight,
pubmed-meshheading:18663996-Down-Regulation,
pubmed-meshheading:18663996-Gene Expression,
pubmed-meshheading:18663996-Humans,
pubmed-meshheading:18663996-Lipid Metabolism,
pubmed-meshheading:18663996-Male,
pubmed-meshheading:18663996-Obesity,
pubmed-meshheading:18663996-RNA, Messenger,
pubmed-meshheading:18663996-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18663996-Risk Factors,
pubmed-meshheading:18663996-Seminal Plasma Proteins,
pubmed-meshheading:18663996-Subcutaneous Fat
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pubmed:year |
2008
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pubmed:articleTitle |
ZAG, a lipid mobilizing adipokine, is downregulated in human obesity.
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pubmed:affiliation |
Department of Nutrition and Food Science, Physiology and Toxicology, University of Navarra, Pamplona, Spain.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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