| pubmed-article:18663236 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18663236 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:18663236 | lifeskim:mentions | umls-concept:C1428114 | lld:lifeskim |
| pubmed-article:18663236 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18663236 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18663236 | pubmed:dateCreated | 2008-7-29 | lld:pubmed |
| pubmed-article:18663236 | pubmed:abstractText | In Drosophila, cryptochrome (cry) encodes a blue-light photoreceptor that mediates light input to circadian oscillators and sustains oscillator function in peripheral tissues. The levels of cry mRNA cycle with a peak at approximately ZT5, which is similar to the phase of Clock (Clk) mRNA cycling in Drosophila. To understand how cry spatial and circadian expression is regulated, a series of cry-Gal4 trans-genes containing different portions of cry upstream and intron 1 sequences were tested for spatial and circadian expression. In fly heads, cry upstream sequences drive constitutive expression in brain oscillator neurons, a novel group of nonoscillator cells in the optic lobe, and peripheral oscillator cells in eyes and antennae. In contrast, cry intron 1 drives rhythmic expression in eyes and antennae, but not brain oscillator neurons. These results demonstrate that intron 1 is sufficient for high-amplitude cry mRNA cycling, show that cry upstream sequences are sufficient for expression in brain oscillator neurons, and suggest that cry spatial and circadian expression are regulated by different elements. | lld:pubmed |
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| pubmed-article:18663236 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18663236 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18663236 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18663236 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:18663236 | pubmed:issn | 0748-7304 | lld:pubmed |
| pubmed-article:18663236 | pubmed:author | pubmed-author:HardinPaul... | lld:pubmed |
| pubmed-article:18663236 | pubmed:author | pubmed-author:Hao Zheng | lld:pubmed |
| pubmed-article:18663236 | pubmed:author | pubmed-author:NgFannyF | lld:pubmed |
| pubmed-article:18663236 | pubmed:author | pubmed-author:Yixiao Liu | lld:pubmed |
| pubmed-article:18663236 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18663236 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:18663236 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18663236 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18663236 | pubmed:pagination | 283-95 | lld:pubmed |
| pubmed-article:18663236 | pubmed:dateRevised | 2011-5-25 | lld:pubmed |
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| pubmed-article:18663236 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18663236 | pubmed:articleTitle | Spatial and circadian regulation of cry in Drosophila. | lld:pubmed |
| pubmed-article:18663236 | pubmed:affiliation | Department of Biology and Center for Research on Biological Clocks, Texas A&M University, College Station, TX 77843-3258, USA. | lld:pubmed |
| pubmed-article:18663236 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18663236 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18663236 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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