One form of the hereditary long-QT syndrome, LQT3-Delta KPQ, is associated with sustained inward sodium current during membrane depolarization. Ranolazine reduces late sodium channel current, and we hypothesized that ranolazine would have beneficial effects on electrical and mechanical cardiac function in LQT3 patients with the SCN5A-DeltaKPQ mutation.
Division of Cardiology, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642-8653, USA. heartajm@heart.rochester.edu
