Linked Life Data

18661786

Source:http://linkedlifedata.com/resource/pubmed/id/18661786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-7-29
pubmed:abstractText
Consumption of 1% sucrose solution supplemented with 0.2% vanillin was studied in two experimental contexts in male mice living under chronic social stress induced by daily experience of defeats in agonistic interactions and leading to development of depression. In the first experiment, vanillin sucrose solution was made available as an option along with water during 10 days for mice living in group home cages. Then the mice were subjected to repeated social defeat stress and during exposure to stress they were provided with both vanillin sucrose solution and water using a free two-bottle choice paradigm. In the other experiment, vanillin sucrose solution was first offered to mice after 8 days of exposure to social defeat stress. Males familiar with vanillin sucrose solution showed vanillin sucrose preference while experiencing defeat stress: consumption of vanillin sucrose solution was about 70% of total liquid consumption. However, the consumption of vanillin sucrose solution per gram of body weight in mice exposed to social stress during 20 days was significantly lower than in control males. In the second experiment, males after 8 days of social defeat stress were found to consume significantly less vanillin sucrose solution as compared to control males. On average, during two weeks of measurements, vanillin sucrose solution intake was less than 20% of total liquid consumption in males. Consumption per gram of body weight also appeared to be significantly lower than in control group. The influence of experimental context on the development of anhedonia measured as a reduction of sucrose solution intake by chronically stressed male mice is discussed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-4677
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
238-46
pubmed:meshHeading
pubmed:articleTitle
[Influence of experimental context on the development of anhedonia in male mice exposed to chronic social stress].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't