Linked Life Data

18661784

Source:http://linkedlifedata.com/resource/pubmed/id/18661784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-7-29
pubmed:abstractText
Thyroxine synthesis inhibitors produced augmentation in predisposition to catalepsy and a decrease of sexual motivation and acoustic startle reflex response in rat. Sensitivity of these behavioral alterations to antidepressants was unknown. Chronic treatment with prototypical antidepressant imipramine (15 mg/kg, 21 days) prevented manifestation of catalepsy expression and sexual motivation reduction in Wistar rats given propylthiouracil (50 mg/l, 28 days) but did not influence startle reflex amplitude. Behavioral recovery induced by imipramine did not attribute to alterations in locomotor activity in open-field test or body weight gain. 5-HT(2A)-receptor mRNA level in the frontal cortex was not changed either. Model of sexual motivation disturbance and catalepsy induced by propylthiouracil in rat seems to be prospective to study the role of thyroid dysfunctions in mechanisms of depression and antidepressant treatment.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0044-4677
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-25
pubmed:meshHeading
pubmed:articleTitle
[Chronic imipramine treatment normalizes decreased sexual motivation and high predisposition to catalepsy induced by propylthiouracil in rat].
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't