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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-10-2
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pubmed:abstractText |
This study investigated whether abnormalities in serotonin transporter binding occur in Parkinson's disease (PD) patients with concurrent depression. We estimated serotonin transporter levels in seven clinically depressed early-stage PD patients and in seven healthy matched-control subjects during a single positron emission tomography (PET) scan with the serotonin transporter radioligand, [(11)C]DASB. Depressed PD patients displayed a wide-spread increase (8-68%) in [(11)C]DASB specific binding outside of the striatum, which was significant in dorsolateral (37%) and prefrontal (68%) cortices. Elevated [(11)C]DASB binding was positively correlated with depressive symptoms but not with disease severity or duration. Compatible with recent PET/[(11)C]DASB findings in major depression, the present preliminary data suggest that increased [(11)C]DASB binding, possibly reflecting greater serotonin transporter density (up-regulation), might be a pathological feature of depression in Parkinson's disease-and possibly a characteristic of depressive illness in general.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1531-8257
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pubmed:author |
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pubmed:copyrightInfo |
(c) 2007 Movement Disorder Society.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1776-80
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pubmed:meshHeading |
pubmed-meshheading:18661545-Aged,
pubmed-meshheading:18661545-Aniline Compounds,
pubmed-meshheading:18661545-Case-Control Studies,
pubmed-meshheading:18661545-Depression,
pubmed-meshheading:18661545-Female,
pubmed-meshheading:18661545-Humans,
pubmed-meshheading:18661545-Male,
pubmed-meshheading:18661545-Middle Aged,
pubmed-meshheading:18661545-Parkinson Disease,
pubmed-meshheading:18661545-Positron-Emission Tomography,
pubmed-meshheading:18661545-Prefrontal Cortex,
pubmed-meshheading:18661545-Protein Binding,
pubmed-meshheading:18661545-Psychiatric Status Rating Scales,
pubmed-meshheading:18661545-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:18661545-Statistics, Nonparametric,
pubmed-meshheading:18661545-Sulfides
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pubmed:year |
2008
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pubmed:articleTitle |
Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASB.
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pubmed:affiliation |
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. isabelle_boileau@CAMH.net
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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