rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
2008-9-15
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pubmed:abstractText |
Previous reports based on small patient numbers suggested that changes in serum HER-2/neu levels may predict response or lack of response to trastuzumab-based therapies in metastatic breast cancer (MBC). The objectives of this study were to pool data from 307 patients with MBC from 7 medical institutions to validate that the serum HER-2/neu profile predicts patient resistance to trastuzumab and to establish a clinically relevant cutoff.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, Humanized,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/trastuzumab
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
pubmed:issn |
0008-543X
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pubmed:author |
pubmed-author:AliSuhail MSM,
pubmed-author:CarneyWalter PWP,
pubmed-author:EstevaFrancisco JFJ,
pubmed-author:FornierMonicaM,
pubmed-author:HarrisLyndsayL,
pubmed-author:KöstlerWolfgang JWJ,
pubmed-author:LiptonAllanA,
pubmed-author:LotzJean-PierreJP,
pubmed-author:LuftnerDianaD,
pubmed-author:PichonMarie-FranceMF,
pubmed-author:Serum HER-2/neu Study Group
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pubmed:copyrightInfo |
(c) 2008 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
113
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1294-301
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18661530-Antibodies, Monoclonal,
pubmed-meshheading:18661530-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:18661530-Antineoplastic Agents,
pubmed-meshheading:18661530-Breast Neoplasms,
pubmed-meshheading:18661530-Disease Progression,
pubmed-meshheading:18661530-Disease-Free Survival,
pubmed-meshheading:18661530-Drug Resistance, Neoplasm,
pubmed-meshheading:18661530-Female,
pubmed-meshheading:18661530-Humans,
pubmed-meshheading:18661530-Predictive Value of Tests,
pubmed-meshheading:18661530-Receptor, erbB-2,
pubmed-meshheading:18661530-Retrospective Studies,
pubmed-meshheading:18661530-Survival Rate,
pubmed-meshheading:18661530-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer.
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pubmed:affiliation |
Department of Hematology-Oncology, Penn State Hershey Cancer Center, Penn State University/Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|