Linked Life Data

18661398

Source:http://linkedlifedata.com/resource/pubmed/id/18661398

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-9-17
pubmed:abstractText
CD40/CD40L interaction on high-grade aggressive lymphomas such as Burkitt lymphoma results in a decrease in proliferation, whereas a transient increase in proliferation and survival in vitro is seen with indolent lymphomas. In this study, cell growth inhibition on human Burkitt lymphoma cell lines CA46 and Raji were obtained with either srhCD40L or pyrrolidine dithiocarbamate (PDTC), a specific inhibitor of NF-kappaB, whereas converse effects on CD40 negative control. Moreover, S phase arrest was demonstrated on CA46 cells in the presence of srhCD40L, and also cell apoptosis following exposed to srhCD40L or PDTC. Furthermore, nuclear factor-kappaB (NF-kappaB) DNA binding activity of CA46 cell extracts was markedly suppressed with srhCD40L or PDTC by electrophoretic mobility shift assays (EMSAs). Thus, the growth inhibition and apoptosis-inducing activity of srhCD40L via CD40-CD40 ligand interaction on Burkitt lymphoma cells was confirmed, and these effects may be attributable to the suppression of NF-kappaB binding activity. Hence, srhCD40L may provide clinical benefits in the treatment of CD40 positive carcinomas including human Burkitt lymphoma.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1029-2403
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1792-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
CD40L-mediated inhibition of NF-kappaB in CA46 Burkitt lymphoma cells promotes apoptosis.
pubmed:affiliation
Department of Hematology, Fujian Institute of Hematology, Union Hospital of Fujian Medical University, Fuzhou, China. zjsywang@pub5.fz.fj.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't