Linked Life Data

18660810

Source:http://linkedlifedata.com/resource/pubmed/id/18660810

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2008-7-30
pubmed:databankReference
pubmed:abstractText
We identified association of restless legs syndrome (RLS) with PTPRD at 9p23-24 in 2,458 affected individuals and 4,749 controls from Germany, Austria, Czechia and Canada. Two independent SNPs in the 5' UTR of splice variants expressed predominantly in the central nervous system showed highly significant P values (rs4626664, P(nominal/lambda corrected) = 5.91 x 10(-10), odds ratio (OR) = 1.44; rs1975197, P(nominal/lambda corrected) = 5.81 x 10(-9), OR = 1.31). This work identifies PTPRD as the fourth genome-wide significant locus for RLS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1546-1718
pubmed:author
pubmed-author:BachmannCornelius GCG, pubmed-author:FrauscherBirgitB, pubmed-author:GiegerChristianC, pubmed-author:GschliesserViolaV, pubmed-author:HöglBirgitB, pubmed-author:HolsboerFlorianF, pubmed-author:IlligThomasT, pubmed-author:KemlinkDavidD, pubmed-author:LichtnerPeterP, pubmed-author:Müller-MyhsokBertramB, pubmed-author:MeitingerThomasT, pubmed-author:MontplaisirJacquesJ, pubmed-author:NevsimalovaSonaS, pubmed-author:OertelWolfgangW, pubmed-author:PaulusWalterW, pubmed-author:PeglauInesI, pubmed-author:PoeweWernerW, pubmed-author:RipkeStephanS, pubmed-author:RoeskeDarinaD, pubmed-author:RouleauGuyG, pubmed-author:SchormairBarbaraB, pubmed-author:SonkaKarelK, pubmed-author:Stiasny-KolsterKarinK, pubmed-author:TanTiong YongTY, pubmed-author:TrenkwalderClaudiaC, pubmed-author:TureckiGustavoG, pubmed-author:VávrováJanaJ, pubmed-author:VodickaPavelP, pubmed-author:WichmannH-ErichHE, pubmed-author:WinkelmannJulianeJ, pubmed-author:XiongLanL, pubmed-author:ZimprichAlexanderA
pubmed:issnType
Electronic
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
946-8
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
PTPRD (protein tyrosine phosphatase receptor type delta) is associated with restless legs syndrome.
pubmed:affiliation
Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't