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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1991-9-9
|
| pubmed:abstractText |
Fibrous polyurethane prostheses were implanted in the carotid arteries and aortae of New Zealand white (NZW) and Chinchilla (CHIN) rabbits. No immediate post-implantation patency was obtained after implantation in the carotid arteries in NZW rabbits. In CHIN rabbits patency up to 1 week was obtained after carotid implantation. Attempts to increase patency rates by administration of 20 mg/kg body weight/day of both dipyridamol (DIP) and acetyl-salicylic acid (ASA) p.o., starting the week before implantation, had an adverse effect; prostheses became occluded within a few hours after implantation. Coagulation tests (Lee and White, Am J Med Sci 145:495-503, 1913) carried out with blood drawn from CHIN rabbits revealed hypercoaguability after administration of either 10 or 20 mg/kg body weight/day of both DIP and ASA compared to pre-medication values. Prostheses implanted in the aortae of both strains remained patent without anti-platelet-aggregation therapy for a 3-month observation period. It is concluded that in the NZW rabbit carotid implantation was not successful due to severe spasmic reactions and that in CHIN rabbits only very short-term patency could be obtained both with and without administration of 10 or 20 mg/kg body weight/day medication DIP and ASA.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0738-1085
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
12
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
164-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1865809-Animals,
pubmed-meshheading:1865809-Aorta,
pubmed-meshheading:1865809-Blood Coagulation,
pubmed-meshheading:1865809-Blood Vessel Prosthesis,
pubmed-meshheading:1865809-Carotid Arteries,
pubmed-meshheading:1865809-Male,
pubmed-meshheading:1865809-Polyurethanes,
pubmed-meshheading:1865809-Prosthesis Failure,
pubmed-meshheading:1865809-Rabbits,
pubmed-meshheading:1865809-Time Factors,
pubmed-meshheading:1865809-Vascular Patency
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Failure to obtain long-term patency after implantation of fibrous polyurethane prostheses in the carotid arteries of rabbits.
|
| pubmed:affiliation |
Laboratory for Cell Biology and Histology, Catholic University of Nijmegen, The Netherlands.
|
| pubmed:publicationType |
Journal Article
|