Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2008-10-30
pubmed:abstractText
Approximately 8% of autosomal recessive retinitis pigmentosa (RP) cases worldwide are due to defects in rod-specific phosphodiesterase PDE6, a tetramer consisting of catalytic (PDE6alpha and PDE6beta) and two regulatory (PDE6gamma) subunits. In mice homozygous for a nonsense Pde6b(rd1) allele, absence of PDE6 activity is associated with retinal disease similar to humans. Although studied for 80 years, the rapid degeneration Pde6b(rd1) phenotype has limited analyses and therapeutic modeling. Moreover, this model does not represent human RP involving PDE6B missense mutations. In the current study the mouse missense allele, Pde6b(H620Q) was characterized further.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10366071, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10393062, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10438872, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10440271, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10549634, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10586951, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-10786833, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11152756, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11171042, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-112243, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11520918, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11826267, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11853759, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-11853772, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-12154183, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-12356839, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-12556383, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-12925369, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-14517541, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15218024, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15240799, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15358079, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15623764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15668239, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15769618, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-15988070, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16123450, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16269358, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16374327, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16547945, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16563379, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-1656438, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16576828, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16595671, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-16641226, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-17044014, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-1710212, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-17138607, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-17267005, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-17699662, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-1847109, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-193183, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-1977087, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-2161252, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-227876, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-3670292, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-4369896, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-5916892, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-6101903, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-6188482, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-6264430, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-6327179, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-6493, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-7489404, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-7493036, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-7724547, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-7891973, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8112981, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8125719, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8182033, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8378322, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-848389, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8595886, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8638127, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-8640555, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-9112990, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-9282169, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-9576942, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-9756475, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-978123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18658088-9811932
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1552-5783
pubmed:author
More...