| pubmed-article:18657281 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C1565860 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C1705323 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C0225828 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C0031621 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:18657281 | lifeskim:mentions | umls-concept:C0251991 | lld:lifeskim |
| pubmed-article:18657281 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18657281 | pubmed:dateCreated | 2008-9-22 | lld:pubmed |
| pubmed-article:18657281 | pubmed:abstractText | Glucocorticoids induce COX-2 expression in rat cardiomyocytes. While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression. Expression of a dominant-negative mutant of p85 subunit of PI3K failed to inhibit CT from inducing COX-2 expression. CT did not activate PI3K/AKT signaling pathway whereas LY29 and WM decreased the activity of PI3K. LY303511 (LY30), a structural analogue and a negative control for PI3K inhibitory activity of LY29, also suppressed COX-2 induction. These data suggest PI3K-independent mechanisms in regulating CT-induced COX-2 expression. LY29 and LY30 do not inhibit glucocorticoid receptor transactivity. Both compounds have been reported to inhibit Casein Kinase 2 activity and modulate potassium and calcium levels independent of PI3K, while LY29 has been reported to inhibit mammalian Target of Rapamycin (mTOR), and DNA-dependent Protein Kinase (DNA-PK). Inhibitor of Casein Kinase 2 (CK2), mTOR or DNA-PK failed to prevent CT from inducing COX-2 expression. Tetraethylammonium (TEA), a potassium channel blocker, and nimodipine, a calcium channel blocker, both attenuated CT from inducing COX-2 gene expression. CT was found to increase intracellular Ca(2+) concentration, which can be inhibited by LY29, TEA or nimodipine. These data suggest a possible role of calcium instead of PI3K in CT-induced COX-2 expression in cardiomyocytes. | lld:pubmed |
| pubmed-article:18657281 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18657281 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18657281 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18657281 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:18657281 | pubmed:issn | 1096-0333 | lld:pubmed |
| pubmed-article:18657281 | pubmed:author | pubmed-author:PERRYR WRW | lld:pubmed |
| pubmed-article:18657281 | pubmed:author | pubmed-author:SunHaipengH | lld:pubmed |
| pubmed-article:18657281 | pubmed:author | pubmed-author:ShevelevaElen... | lld:pubmed |
| pubmed-article:18657281 | pubmed:author | pubmed-author:XuBeibeiB | lld:pubmed |
| pubmed-article:18657281 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18657281 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:18657281 | pubmed:volume | 232 | lld:pubmed |
| pubmed-article:18657281 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18657281 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18657281 | pubmed:pagination | 25-32 | lld:pubmed |
| pubmed-article:18657281 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:meshHeading | pubmed-meshheading:18657281... | lld:pubmed |
| pubmed-article:18657281 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18657281 | pubmed:articleTitle | LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism. | lld:pubmed |
| pubmed-article:18657281 | pubmed:affiliation | Interdisciplinary Graduate Program of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85724, USA. | lld:pubmed |
| pubmed-article:18657281 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18657281 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:18657281 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:29527 | entrezgene:pubmed | pubmed-article:18657281 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18657281 | lld:entrezgene |
