Linked Life Data

18656690

Source:http://linkedlifedata.com/resource/pubmed/id/18656690

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-7-28
pubmed:abstractText
Acute mixed lineage leukemia (AMLL) is a rare form of leukemia in which both myeloid and lymphoid markers are present. Few chromosome abnormalities have been identified associated with this form of leukemia. A translocation involving the long arms of chromosomes 6 and 14 was previously described in four young individuals with acute leukemia and in three of these cases the diagnosis was mixed lineage. We identified a translocation involving the same chromosomes in two additional cases of adults with AMLL. The q32 breakpoint on chromosome 14 is shared by all six cases and five out of six cases also share the q25 breakpoint on chromosome 6. The rarity of the t(6;14) and the AMLL suggests a non-random association between these two events. The near cryptic appearance of the translocation might indicate that its occurrence is underestimated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1873-4456
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
185
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-31
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Acute mixed lineage leukemia and a t(6;14)(q25;q32) in two adults.
pubmed:affiliation
Department of Pathology, Division of Molecular Pathology, Johns Hopkins University, 600 N. Wolfe Street, Park SB 202, Baltimore, MD 21287, USA.
pubmed:publicationType
Journal Article, Case Reports