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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-8-15
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pubmed:abstractText |
The associations of the C825T polymorphism (rs5443) of the G-protein beta3 subunit (GNB3) gene and eight adjacent single nucleotide polymorphisms (SNPs) with diabetes were examined using a Japanese population (n (M/W): 2956 (1335/1621); age: 63.0+/-10.2 years). Fasting plasma glucose (FPG) levels were significantly associated with the C825T polymorphism and two flanking SNPs (rs2301339 and rs5446) (p=0.002, 0.001, and 0.008, respectively). A case-control association study of the C825T polymorphism with diabetes using multiple logistic regression analysis showed a significant association of the genotypes TT+TC with an odds ratio of 0.62 (p=0.008) independent of age, gender, and BMI. The effects of salt consumption on the association were then examined (n=1635). The FPG levels were significantly associated with the C825T polymorphism only in subjects with low salt consumption (<12.44 g/day) (p=0.002). A case-control association study also showed a significant association with diabetes only in subjects with low salt consumption (p=0.006).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1090-2104
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pubmed:author |
pubmed-author:DaimonMakotoM,
pubmed-author:EmiMitsuruM,
pubmed-author:FukaoAkiraA,
pubmed-author:HopkinsPaul NPN,
pubmed-author:HuntSteven CSC,
pubmed-author:JimbuYumiY,
pubmed-author:KamedaWataruW,
pubmed-author:KarasawaShigeruS,
pubmed-author:KatoTakeoT,
pubmed-author:KawataSumioS,
pubmed-author:KubotaIsaoI,
pubmed-author:MuramatsuMasaakiM,
pubmed-author:OizumiToshihideT,
pubmed-author:SasakiSatoshiS,
pubmed-author:SatoHidenoriH,
pubmed-author:SusaShinjiS,
pubmed-author:ToriyamaSayumiS,
pubmed-author:WadaKirikoK
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pubmed:issnType |
Electronic
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pubmed:day |
26
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pubmed:volume |
374
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
576-80
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18656447-Aged,
pubmed-meshheading:18656447-Asian Continental Ancestry Group,
pubmed-meshheading:18656447-Blood Glucose,
pubmed-meshheading:18656447-Case-Control Studies,
pubmed-meshheading:18656447-Cross-Sectional Studies,
pubmed-meshheading:18656447-Diabetes Mellitus, Type 2,
pubmed-meshheading:18656447-Fasting,
pubmed-meshheading:18656447-Genetic Linkage,
pubmed-meshheading:18656447-Genetic Predisposition to Disease,
pubmed-meshheading:18656447-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:18656447-Humans,
pubmed-meshheading:18656447-Japan,
pubmed-meshheading:18656447-Middle Aged,
pubmed-meshheading:18656447-Polymorphism, Single Nucleotide,
pubmed-meshheading:18656447-Sodium Chloride, Dietary
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pubmed:year |
2008
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pubmed:articleTitle |
Salt consumption-dependent association of the GNB3 gene polymorphism with type 2 DM.
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pubmed:affiliation |
Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990 9585, Japan. mdaimon@med.id.yamagata-u.ac.jp
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pubmed:publicationType |
Journal Article
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