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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-8-14
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pubmed:abstractText |
Immunoglobulin A (IgA) is generated in the gut by both T cell-dependent and T cell-independent processes. The sites and the mechanisms for T cell-independent IgA synthesis remain elusive. Here we show that isolated lymphoid follicles (ILFs) were sites where induction of activation-induced cytidine deaminase (AID) and IgA class switching of B cells took place in the absence of T cells. We also show that formation of ILFs was regulated by interactions between lymphoid tissue-inducer cells expressing the nuclear receptor ROR gamma t (ROR gamma t(+)LTi cells) and stromal cells (SCs). Activation of SCs by ROR gamma t(+)LTi cells through lymphotoxin (LT)-beta receptor (LT beta R) and simultaneously by bacteria through TLRs induced recruitment of dendritic cells (DCs) and B cells and formation of ILFs. These findings provide insight into the crosstalk between bacteria, ROR gamma t(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytidine Deaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphotoxin beta Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Rorc protein, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1097-4180
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-71
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18656387-Animals,
pubmed-meshheading:18656387-B-Lymphocytes,
pubmed-meshheading:18656387-Cell Communication,
pubmed-meshheading:18656387-Cytidine Deaminase,
pubmed-meshheading:18656387-Cytokines,
pubmed-meshheading:18656387-Dendritic Cells,
pubmed-meshheading:18656387-Gastrointestinal Tract,
pubmed-meshheading:18656387-Immunoglobulin A,
pubmed-meshheading:18656387-Immunoglobulin Class Switching,
pubmed-meshheading:18656387-Lymphoid Tissue,
pubmed-meshheading:18656387-Lymphotoxin beta Receptor,
pubmed-meshheading:18656387-Mice,
pubmed-meshheading:18656387-Mice, Knockout,
pubmed-meshheading:18656387-Mice, Mutant Strains,
pubmed-meshheading:18656387-Nuclear Receptor Subfamily 1, Group F, Member 3,
pubmed-meshheading:18656387-Receptors, Retinoic Acid,
pubmed-meshheading:18656387-Receptors, Thyroid Hormone,
pubmed-meshheading:18656387-Stromal Cells,
pubmed-meshheading:18656387-T-Lymphocytes
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pubmed:year |
2008
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pubmed:articleTitle |
Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut.
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pubmed:affiliation |
Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1-7-22, Tsurumi, Yokohama, 230-0045, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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