Linked Life Data

18656208

Source:http://linkedlifedata.com/resource/pubmed/id/18656208

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2008-9-1
pubmed:abstractText
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome with familial and sporadic forms. We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 1265 neurologically healthy controls to assess the Alzheimer-associated apolipoprotein E (APOE) epsilon4 gene variant as a possible risk factor for ALS. While no major influence of APOE epsilon4 on disease risk was detected, a gene dose-dependent effect with lower age at onset of sporadic ALS in epsilon4 carriers was found (p=0.027). These data support APOE epsilon4 as a subordinate contributing factor in ALS.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0022-510X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
273
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.
pubmed:affiliation
Department of Neurochemistry and Psychiatry, Sahlgrenska University Hospital, Göteborg University, Sweden. henrik.zetterberg@clinchem.gu.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't