Source:http://linkedlifedata.com/resource/pubmed/id/18651826
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
Metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) participate in the degeneration of the extracellular matrix and are associated with carcinogenesis. MMP-2 is one of the main metalloproteinases active in neoplasia and is a marker of the malignant phenotype. Since the biological behavior of medullary thyroid carcinoma (MTC) varies widely, the present study was undertaken to determine if there is a correlation between the clinical evolution of MTC and the immunohistochemically detected expression of these enzymes in thyroid surgical specimens containing MTC. If so, their expression would be a novel indicator of the prognosis of MTC.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1050-7256
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
865-71
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pubmed:meshHeading |
pubmed-meshheading:18651826-Adolescent,
pubmed-meshheading:18651826-Adult,
pubmed-meshheading:18651826-Aged,
pubmed-meshheading:18651826-Carcinoma, Medullary,
pubmed-meshheading:18651826-Child,
pubmed-meshheading:18651826-Female,
pubmed-meshheading:18651826-Humans,
pubmed-meshheading:18651826-Immunohistochemistry,
pubmed-meshheading:18651826-Male,
pubmed-meshheading:18651826-Matrix Metalloproteinase 2,
pubmed-meshheading:18651826-Middle Aged,
pubmed-meshheading:18651826-Prognosis,
pubmed-meshheading:18651826-Thyroid Neoplasms,
pubmed-meshheading:18651826-Tissue Inhibitor of Metalloproteinase-2,
pubmed-meshheading:18651826-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of metalloproteinase 2 (TIMP-2) in medullary thyroid carcinoma: prognostic implications.
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pubmed:affiliation |
Head and Neck Surgery Service of the Brazilian Institute for Cancer Control (IBCC), São Paulo, Brazil. bgcavalheiro@yahoo.com.br
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pubmed:publicationType |
Journal Article
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