| pubmed-article:18651302 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18651302 | lifeskim:mentions | umls-concept:C0005716 | lld:lifeskim |
| pubmed-article:18651302 | lifeskim:mentions | umls-concept:C2709248 | lld:lifeskim |
| pubmed-article:18651302 | lifeskim:mentions | umls-concept:C2708283 | lld:lifeskim |
| pubmed-article:18651302 | lifeskim:mentions | umls-concept:C0036496 | lld:lifeskim |
| pubmed-article:18651302 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:18651302 | pubmed:dateCreated | 2008-11-7 | lld:pubmed |
| pubmed-article:18651302 | pubmed:abstractText | Blastomycosis is a granulomatous infection caused by the thermally dimorphic fungus, Blastomyces dermatitidis, for which seasonal variation has been proposed. We conducted a retrospective review of medical records of 324 patients with blastomycosis in Manitoba and northwestern Ontario. The average age of patients at the time of diagnosis was 39+/-20 (range, 0-85) years. Symptoms referable to blastomycosis were first noted in the autumn and winter (September to February) by 63% of the patients. The seasonal distribution of cases was different for localized pulmonary infection than the disseminated disease (P<0.0001). For localized lung disease, the peak incidence of symptom onset occurred in the autumn, and lowest incidence in the spring; one half (50%) of the patients with diffuse lung disease had onset of symptoms in the spring months and a few (11%) cases occurred during the summer. We noted a distinct seasonal variation in the clinical presentation of blastomycosis. The observed pattern suggests that summer environmental exposure and acquisition of the infection results in an early (1-6 months) localized pneumonia in the majority of cases, followed by later (4-9 months) reactivation or slow progression of asymptomatic infection resulting in isolated extrapulmonary or disseminated hematogenous disease in the minority. | lld:pubmed |
| pubmed-article:18651302 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18651302 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18651302 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18651302 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18651302 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:18651302 | pubmed:issn | 1369-3786 | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:EmbilJohn MJM | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:TrepmanEllyE | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:HammondGregG | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:LimerickBillB | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:WiebeLyleL | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:MacdonaldKerr... | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:Bruce LightRR | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:KraltDougD | lld:pubmed |
| pubmed-article:18651302 | pubmed:author | pubmed-author:SarsfieldPete... | lld:pubmed |
| pubmed-article:18651302 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18651302 | pubmed:volume | 46 | lld:pubmed |
| pubmed-article:18651302 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18651302 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18651302 | pubmed:pagination | 835-41 | lld:pubmed |
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| pubmed-article:18651302 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18651302 | pubmed:articleTitle | Seasonal variations in the clinical presentation of pulmonary and extrapulmonary blastomycosis. | lld:pubmed |
| pubmed-article:18651302 | pubmed:affiliation | Section of Infectious Diseases, Department of Medicine, University of Manitoba, Winnipeg. | lld:pubmed |
| pubmed-article:18651302 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18651302 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18651302 | lld:pubmed |
