Source:http://linkedlifedata.com/resource/pubmed/id/18651302
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2008-11-7
|
| pubmed:abstractText |
Blastomycosis is a granulomatous infection caused by the thermally dimorphic fungus, Blastomyces dermatitidis, for which seasonal variation has been proposed. We conducted a retrospective review of medical records of 324 patients with blastomycosis in Manitoba and northwestern Ontario. The average age of patients at the time of diagnosis was 39+/-20 (range, 0-85) years. Symptoms referable to blastomycosis were first noted in the autumn and winter (September to February) by 63% of the patients. The seasonal distribution of cases was different for localized pulmonary infection than the disseminated disease (P<0.0001). For localized lung disease, the peak incidence of symptom onset occurred in the autumn, and lowest incidence in the spring; one half (50%) of the patients with diffuse lung disease had onset of symptoms in the spring months and a few (11%) cases occurred during the summer. We noted a distinct seasonal variation in the clinical presentation of blastomycosis. The observed pattern suggests that summer environmental exposure and acquisition of the infection results in an early (1-6 months) localized pneumonia in the majority of cases, followed by later (4-9 months) reactivation or slow progression of asymptomatic infection resulting in isolated extrapulmonary or disseminated hematogenous disease in the minority.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
1369-3786
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
46
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
835-41
|
| pubmed:meshHeading |
pubmed-meshheading:18651302-Adolescent,
pubmed-meshheading:18651302-Adult,
pubmed-meshheading:18651302-Aged,
pubmed-meshheading:18651302-Aged, 80 and over,
pubmed-meshheading:18651302-Blastomyces,
pubmed-meshheading:18651302-Blastomycosis,
pubmed-meshheading:18651302-Chi-Square Distribution,
pubmed-meshheading:18651302-Child,
pubmed-meshheading:18651302-Child, Preschool,
pubmed-meshheading:18651302-Female,
pubmed-meshheading:18651302-Humans,
pubmed-meshheading:18651302-Incidence,
pubmed-meshheading:18651302-Infant,
pubmed-meshheading:18651302-Infant, Newborn,
pubmed-meshheading:18651302-Lung,
pubmed-meshheading:18651302-Lung Diseases, Fungal,
pubmed-meshheading:18651302-Male,
pubmed-meshheading:18651302-Manitoba,
pubmed-meshheading:18651302-Middle Aged,
pubmed-meshheading:18651302-Ontario,
pubmed-meshheading:18651302-Retrospective Studies,
pubmed-meshheading:18651302-Seasons,
pubmed-meshheading:18651302-Sex Distribution
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Seasonal variations in the clinical presentation of pulmonary and extrapulmonary blastomycosis.
|
| pubmed:affiliation |
Section of Infectious Diseases, Department of Medicine, University of Manitoba, Winnipeg.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|