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pubmed:abstractText |
In the ischemic or hypoxic heart, an impairment of electrical cell-to-cell coupling and a dephosphorylation of the connexins that comprise the gap junction channel were observed. However, it remains to be elucidated whether the dephosphorylation of the connexin during hypoxia is due to alterations in the ionic strength of Ca(2+) or H(+), and how the activation of protein kinase A (PKA) affects the hypoxia-induced abnormal function of the gap junction.
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