Source:http://linkedlifedata.com/resource/pubmed/id/18650775
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-12-16
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pubmed:abstractText |
The long pentraxin 3 (PTX3) is an important element of the innate immune system and has potential as a diagnostic tool in inflammatory conditions. We studied PTX3 in patients admitted to an intensive care unit with severe meningococcal disease and compared it with the short pentraxin C-reactive protein (CRP). Twenty-six patients with meningococcal disease were studied, 17 patients presented with meningococcal septic shock (shock group), and 9 patients presented with meningococcal meningitis or bacteremia (no-shock group). Pentraxin 3 and CRP were measured by enzyme-linked immunosorbent assay. High plasma concentrations of PTX3 (median, 579 microg/L) were seen at admission in patients with meningococcal disease. Concentrations were significantly higher in patients with shock compared with patients without shock (medians, 801 and 256 microg/L, respectively; P = 0.006). In contrast, CRP at admission was lower in the shock group as compared with the no-shock group (medians, 58 and 165 mg/L, respectively; P = 0.008). High PTX3 and low CRP concentration at admission discriminated between presence and absence of shock (area under the receiver operating characteristic curve, 0.85; P = 0.007 for PTX3 and area under the receiver operating characteristic curve, 0.84; P = 0.01 for CRP). PTX3 did not correlate with disease severity (pediatric risk of mortality) and days spent in the intensive care unit. PTX3 at admission and PTX3 peak concentration both showed a negative correlation with plasma fibrinogen concentrations. C-reactive protein concentration at admission correlated negatively with disease severity. In conclusion, PTX3 was an early indicator of shock in patients with severe meningococcal disease that followed a pattern of induction distinct from CRP.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1540-0514
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-32
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pubmed:meshHeading |
pubmed-meshheading:18650775-Adolescent,
pubmed-meshheading:18650775-Adult,
pubmed-meshheading:18650775-Bacteremia,
pubmed-meshheading:18650775-Biological Markers,
pubmed-meshheading:18650775-C-Reactive Protein,
pubmed-meshheading:18650775-Child,
pubmed-meshheading:18650775-Child, Preschool,
pubmed-meshheading:18650775-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:18650775-Female,
pubmed-meshheading:18650775-Humans,
pubmed-meshheading:18650775-Immunity, Innate,
pubmed-meshheading:18650775-Infant,
pubmed-meshheading:18650775-Male,
pubmed-meshheading:18650775-Meningitis, Meningococcal,
pubmed-meshheading:18650775-Retrospective Studies,
pubmed-meshheading:18650775-Serum Amyloid P-Component,
pubmed-meshheading:18650775-Shock, Septic
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pubmed:year |
2009
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pubmed:articleTitle |
Pentraxin 3 and C-reactive protein in severe meningococcal disease.
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pubmed:affiliation |
Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands. t.sprong@aig.umcn.nl
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pubmed:publicationType |
Journal Article
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