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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0039194,
umls-concept:C0439677,
umls-concept:C0597357,
umls-concept:C0871261,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1519595,
umls-concept:C1540293,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
30
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pubmed:dateCreated |
2008-7-30
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pubmed:abstractText |
The B7 family member B7-H3 (CD276) plays important roles in immune responses. However, the function of B7-H3 remains controversial. We found that murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TLT-2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TLT-2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. Blockade of the B7-H3:TLT-2 pathway with a mAb against B7-H3 or TLT-2 efficiently inhibited contact hypersensitivity responses. Our results demonstrate a direct interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-11224528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-11861596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12055244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12385029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12645956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12776204,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12893276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12906861,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12925852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-12939639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-14515261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15047568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15122199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15187106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15294965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15317945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15494491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15568026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15682454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15771580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-15961727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16388488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16489649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16670310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16713537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16782226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-16982862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17109987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17110943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17610414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17615586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17686830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-17825429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-18042703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-18650376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-8287475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18650384-8671681
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/B7 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/CD276 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cd276 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/TREML2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1091-6490
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
10495-500
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18650384-Animals,
pubmed-meshheading:18650384-Antigens, CD,
pubmed-meshheading:18650384-Antigens, CD3,
pubmed-meshheading:18650384-Antigens, CD80,
pubmed-meshheading:18650384-B7 Antigens,
pubmed-meshheading:18650384-CD8-Positive T-Lymphocytes,
pubmed-meshheading:18650384-Dermatitis, Contact,
pubmed-meshheading:18650384-Gene Expression Regulation,
pubmed-meshheading:18650384-Humans,
pubmed-meshheading:18650384-Immune System,
pubmed-meshheading:18650384-Interferon-gamma,
pubmed-meshheading:18650384-Lymphocyte Activation,
pubmed-meshheading:18650384-Mice,
pubmed-meshheading:18650384-Mice, Inbred BALB C,
pubmed-meshheading:18650384-Rats,
pubmed-meshheading:18650384-Receptors, Immunologic
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pubmed:year |
2008
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