Source:http://linkedlifedata.com/resource/pubmed/id/18650090
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
16
|
pubmed:dateCreated |
2008-8-11
|
pubmed:abstractText |
In search for a new antibacterial agent with improved antimicrobial spectrum and potency, we designed and synthesized a series of novel 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones 7a-h by convergent synthesis approach. All the synthesized compounds were assayed for their in-vitro antibacterial activities against gram-negative and gram-positive bacteria. The preliminary structure-activity relationship, to elucidate the essential structure requirements for the antimicrobial activity that results into anti-MRSA (methicillin-resistant S. aureus) potential, has been described. Amongst the synthesized compounds 7d, 7e, 7f and 7h were found to possess activity against methicillin-resistant S. aureus in addition to the activity against other bacterial strains such as E. faecalis, S. pneumoniae, and E. coli.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1464-3405
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:day |
15
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
4678-81
|
pubmed:meshHeading |
pubmed-meshheading:18650090-Anti-Bacterial Agents,
pubmed-meshheading:18650090-Carboxylic Acids,
pubmed-meshheading:18650090-Chemistry, Pharmaceutical,
pubmed-meshheading:18650090-Chromones,
pubmed-meshheading:18650090-Drug Design,
pubmed-meshheading:18650090-Escherichia coli,
pubmed-meshheading:18650090-Humans,
pubmed-meshheading:18650090-Methicillin Resistance,
pubmed-meshheading:18650090-Microbial Sensitivity Tests,
pubmed-meshheading:18650090-Models, Chemical,
pubmed-meshheading:18650090-Molecular Structure,
pubmed-meshheading:18650090-Staphylococcus aureus,
pubmed-meshheading:18650090-Structure-Activity Relationship,
pubmed-meshheading:18650090-Tetrazoles
|
pubmed:year |
2008
|
pubmed:articleTitle |
Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: synthesis, SAR, and in-vitro assessment.
|
pubmed:affiliation |
Drug Discovery Research, Chemistry, Wockhardt Research Centre, D-4, MIDC, Chikalthana, Aurangabad 431 210, India.
|
pubmed:publicationType |
Journal Article
|