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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
The rare allele of a non-synonymous interleukin 23 receptor (IL23R) single nucleotide polymorphism (SNP) rs11209026 (p.Arg381Gln) confers strong protection against Crohn disease (CD) and psoriasis. Other IL23R variants also exhibit association with CD, genetically independent of rs11209026. In rheumatoid arthritis (RA), IL23 is an important determinant of the production of IL17A, a cytokine of consequence in inflammation and bone destruction. While there is no previous support for strong association of IL23R with RA, the possibility of a weaker role for IL23R variants in the aetiology of RA cannot be eliminated.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1468-2060
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pubmed:author |
pubmed-author:ChapmanP TPT,
pubmed-author:CoxL MLM,
pubmed-author:DalbethNN,
pubmed-author:HarrisonA AAA,
pubmed-author:HightonJJ,
pubmed-author:Hollis-MoffattJ EJE,
pubmed-author:JonesP B BPB,
pubmed-author:MerrimanM EME,
pubmed-author:MerrimanT RTR,
pubmed-author:O'DonnellJ LJL,
pubmed-author:RodgerR ARA,
pubmed-author:RowleyK AKA,
pubmed-author:StampL KLK
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1340-4
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pubmed:meshHeading |
pubmed-meshheading:18647855-Adult,
pubmed-meshheading:18647855-Arthritis, Rheumatoid,
pubmed-meshheading:18647855-Case-Control Studies,
pubmed-meshheading:18647855-Cohort Studies,
pubmed-meshheading:18647855-Female,
pubmed-meshheading:18647855-Gene Frequency,
pubmed-meshheading:18647855-Genetic Predisposition to Disease,
pubmed-meshheading:18647855-Humans,
pubmed-meshheading:18647855-Linkage Disequilibrium,
pubmed-meshheading:18647855-Male,
pubmed-meshheading:18647855-Middle Aged,
pubmed-meshheading:18647855-Polymorphism, Single Nucleotide,
pubmed-meshheading:18647855-Receptors, Interleukin
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pubmed:year |
2009
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pubmed:articleTitle |
Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis.
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pubmed:affiliation |
Department of Biochemistry, University of Otago, Dunedin, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Meta-Analysis
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