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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2008-10-9
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pubmed:abstractText |
The Wnt/beta-catenin and cAMP signaling pathways play an important role in adrenal cortex tumorigenesis. Somatic activating mutations of the beta-catenin gene (CTNNB1) are the most frequent genetic defects identified both in adrenocortical adenomas (ACAs) and adrenocortical cancers (ACCs). PRKAR1A mutations leading to cAMP pathway dysregulation are observed in primary pigmented nodular adrenocortical diseases (PPNADs) and some sporadic ACAs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0021-972X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4135-40
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pubmed:meshHeading |
pubmed-meshheading:18647815-Adenoma,
pubmed-meshheading:18647815-Adolescent,
pubmed-meshheading:18647815-Adrenal Cortex Neoplasms,
pubmed-meshheading:18647815-Adult,
pubmed-meshheading:18647815-Aged,
pubmed-meshheading:18647815-Aged, 80 and over,
pubmed-meshheading:18647815-Child,
pubmed-meshheading:18647815-Cyclic AMP,
pubmed-meshheading:18647815-Cyclic AMP-Dependent Protein Kinase RIalpha Subunit,
pubmed-meshheading:18647815-DNA Mutational Analysis,
pubmed-meshheading:18647815-Disease Progression,
pubmed-meshheading:18647815-Female,
pubmed-meshheading:18647815-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18647815-Humans,
pubmed-meshheading:18647815-Male,
pubmed-meshheading:18647815-Middle Aged,
pubmed-meshheading:18647815-Mutation,
pubmed-meshheading:18647815-Neoplasm Invasiveness,
pubmed-meshheading:18647815-Signal Transduction,
pubmed-meshheading:18647815-Tumor Burden,
pubmed-meshheading:18647815-Wnt Proteins,
pubmed-meshheading:18647815-beta Catenin
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pubmed:year |
2008
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pubmed:articleTitle |
Wnt/beta-catenin and 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A signaling pathways alterations and somatic beta-catenin gene mutations in the progression of adrenocortical tumors.
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pubmed:affiliation |
Service des Maladies Endocriniennes et Métaboliques, Hôpital Cochin, 75014 Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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