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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-10-16
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pubmed:abstractText |
We investigated the effects of angiogenic gene therapy with adenoviral placental growth factor(131) (AdPlGF) on aerobic capacity and exercise tolerance in a rabbit hindlimb ischaemia model. We also assessed whether strong angiogenic changes such as capillary arterialization and formation of artery-venous shunts compromise oxygen transport to target tissues resulting in suboptimal therapeutic efficacy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0008-6363
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-70
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pubmed:dateRevised |
2009-11-25
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pubmed:meshHeading |
pubmed-meshheading:18647755-Acidosis,
pubmed-meshheading:18647755-Adenoviridae,
pubmed-meshheading:18647755-Animals,
pubmed-meshheading:18647755-Disease Models, Animal,
pubmed-meshheading:18647755-Edema,
pubmed-meshheading:18647755-Energy Metabolism,
pubmed-meshheading:18647755-Exercise Tolerance,
pubmed-meshheading:18647755-Gene Therapy,
pubmed-meshheading:18647755-Genetic Vectors,
pubmed-meshheading:18647755-Hindlimb,
pubmed-meshheading:18647755-Ischemia,
pubmed-meshheading:18647755-Magnetic Resonance Spectroscopy,
pubmed-meshheading:18647755-Mice,
pubmed-meshheading:18647755-Muscle, Skeletal,
pubmed-meshheading:18647755-Neovascularization, Physiologic,
pubmed-meshheading:18647755-Pregnancy Proteins,
pubmed-meshheading:18647755-Rabbits,
pubmed-meshheading:18647755-Regional Blood Flow,
pubmed-meshheading:18647755-Time Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Therapeutic angiogenesis with placental growth factor improves exercise tolerance of ischaemic rabbit hindlimbs.
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pubmed:affiliation |
Department of Molecular Medicine, A.I. Virtanen Institute, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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