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pubmed-article:18647634pubmed:abstractTextThere is increasing interest in routine vaccination of children against influenza. We use an age-structured model to demonstrate that the long-term incidence of influenza A could decrease by 11-21% in the overall population by vaccinating individuals aged 6 to <24 months, and by 22-38% and 65-97% through targeting those aged 6 to <60 months and 6 months to 16 years, respectively. The corresponding reductions predicted for influenza B were 25-35%, 44-69% and 85-96%, respectively. These results are sensitive to assumptions about contact patterns and several parameters, including the vaccine efficacy among those aged <24 months, require further study. Consistently high levels of vaccination coverage among pre-school children has the potential to bring benefits to both those vaccinated and the community.lld:pubmed
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pubmed-article:18647634pubmed:articleTitleEstimating the impact of childhood influenza vaccination programmes in England and Wales.lld:pubmed
pubmed-article:18647634pubmed:affiliationModelling and Economics Unit, Health Protection Agency Centre for Infections, 61 Colindale Avenue, Colindale, London NW9 5HT, UK. emilia.vynnycky@hpa.org.uklld:pubmed
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