Linked Life Data

18646053

Source:http://linkedlifedata.com/resource/pubmed/id/18646053

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2008-7-28
pubmed:abstractText
Nearly 85% of the men who will die of prostate cancer (PCa) have skeletal metastases present. The ability of PCa cells to interact with the microenvironment determines the success of the tumor cell to form metastatic lesions. The ability to bind to human bone marrow endothelial (HBME) cells and undergo transendothelial cell migration are key steps in allowing the PCa cell to extravasate from the bone microvasculature and invade the bone stroma. We have previously demonstrated that monoctyte chemoattractant protein 1 (MCP-1; CCL2) is expressed by HBME cells and promotes PCa proliferation and migration. In the current study, we demonstrate that the CCL2 stimulation of PCa cells activates the small GTPase, Rac through the actin-associated protein PCNT1. Activation of Rac GTPase is accompanied by morphologic changes and the ability of the cells to undergo diapedesis through HBME cells. These data suggest a role for HBME-secreted CCL2 in promoting PCa cell extravasation into the bone microenvironment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1097-4644
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1587-97
pubmed:meshHeading
pubmed-meshheading:18646053-Actins, pubmed-meshheading:18646053-Bone Neoplasms, pubmed-meshheading:18646053-Cell Line, Tumor, pubmed-meshheading:18646053-Cell Movement, pubmed-meshheading:18646053-Chemokine CCL2, pubmed-meshheading:18646053-Cytoskeleton, pubmed-meshheading:18646053-Endothelial Cells, pubmed-meshheading:18646053-Enzyme Activation, pubmed-meshheading:18646053-Gene Expression Regulation, Neoplastic, pubmed-meshheading:18646053-Humans, pubmed-meshheading:18646053-Male, pubmed-meshheading:18646053-Neoplasm Proteins, pubmed-meshheading:18646053-Nuclear Pore Complex Proteins, pubmed-meshheading:18646053-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:18646053-Prostatic Neoplasms, pubmed-meshheading:18646053-Protein Transport, pubmed-meshheading:18646053-rac GTP-Binding Proteins
pubmed:year
2008
pubmed:articleTitle
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac.
pubmed:affiliation
Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural