|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0023474,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0031727,
umls-concept:C0242656,
umls-concept:C0243095,
umls-concept:C0332167,
umls-concept:C0935989,
umls-concept:C1514562,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221,
umls-concept:C2003874
|
|
pubmed:issue |
29
|
|
pubmed:dateCreated |
2008-10-9
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|
pubmed:abstractText |
Kinase domain (KD) mutations in the BCR-ABL gene are associated with resistance to imatinib in chronic myeloid leukemia (CML) but their incidence and prognostic significance in chronic phase (CP) patients without resistance are unclear.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1527-7755
|
|
pubmed:author |
pubmed-author:ApperleyJane FJF,
pubmed-author:BuaMarcoM,
pubmed-author:GoldmanJohn MJM,
pubmed-author:KaedaJaspalJ,
pubmed-author:KhorashadJamshid SJS,
pubmed-author:MarinDavidD,
pubmed-author:MilojkovicDraganaD,
pubmed-author:OlavarriaEduardoE,
pubmed-author:ReidAlistair GAG,
pubmed-author:SzydloRichardR,
pubmed-author:de LavalladeHuguesH
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
10
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4806-13
|
|
pubmed:meshHeading |
pubmed-meshheading:18645191-Adolescent,
pubmed-meshheading:18645191-Adult,
pubmed-meshheading:18645191-Aged,
pubmed-meshheading:18645191-Antineoplastic Agents,
pubmed-meshheading:18645191-Chronic Disease,
pubmed-meshheading:18645191-Disease Progression,
pubmed-meshheading:18645191-Female,
pubmed-meshheading:18645191-Genes, abl,
pubmed-meshheading:18645191-Humans,
pubmed-meshheading:18645191-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:18645191-Male,
pubmed-meshheading:18645191-Middle Aged,
pubmed-meshheading:18645191-Mutation,
pubmed-meshheading:18645191-Phosphotransferases,
pubmed-meshheading:18645191-Piperazines,
pubmed-meshheading:18645191-Protein Structure, Tertiary,
pubmed-meshheading:18645191-Pyrimidines
|
|
pubmed:year |
2008
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|
pubmed:articleTitle |
Finding of kinase domain mutations in patients with chronic phase chronic myeloid leukemia responding to imatinib may identify those at high risk of disease progression.
|
|
pubmed:affiliation |
Department of Haematology, Hammersmith Hospitals Trust, Imperial College London, Du Cane Rd, London W12 0NN, United Kingdom.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
