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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
In order to study the effect of 5'-modification of 2'-deoxynucleoside on its anti-HCV activity, several analogues were synthesized and evaluated. Among the analogues, a 5'-deoxy-5'-phenacylated analogue exhibited a good anti-HCV activity with an EC(50) of 15.1 microM. This compound is expected to operate via a type of mechanism that does not involve a generally known 5'-O-triphosphorylation process.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3405
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4638-41
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pubmed:meshHeading |
pubmed-meshheading:18644724-Antiviral Agents,
pubmed-meshheading:18644724-Chemistry, Pharmaceutical,
pubmed-meshheading:18644724-DNA, Viral,
pubmed-meshheading:18644724-Deoxyadenosines,
pubmed-meshheading:18644724-Drug Design,
pubmed-meshheading:18644724-Hepacivirus,
pubmed-meshheading:18644724-Hepatitis C,
pubmed-meshheading:18644724-Humans,
pubmed-meshheading:18644724-Models, Chemical,
pubmed-meshheading:18644724-Nucleosides,
pubmed-meshheading:18644724-Phosphorylation,
pubmed-meshheading:18644724-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Synthesis and evaluation of 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.
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pubmed:affiliation |
Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan. ikejim@osaka-ohtani.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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