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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7-8
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
P-glycoprotein, the gene product of multidrug-resistant transporter-1 (MDR1), confers multidrug resistance against antineoplastic agents but also affects the kinetic disposition of some drugs and carcinogens. MDR1 C3435T polymorphism influences the development of colon cancer and adult acute myeloid leukemia by the association with transporting carcinogen. The aim of this study was to clarify the association of MDR1 C3435T polymorphism with susceptibility to gastric cancer and peptic ulcers in patients with Japanese H. pylori infection.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-4
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pubmed:meshHeading |
pubmed-meshheading:18644389-Aged,
pubmed-meshheading:18644389-Alleles,
pubmed-meshheading:18644389-Asian Continental Ancestry Group,
pubmed-meshheading:18644389-Female,
pubmed-meshheading:18644389-Genetic Predisposition to Disease,
pubmed-meshheading:18644389-Genotype,
pubmed-meshheading:18644389-Helicobacter Infections,
pubmed-meshheading:18644389-Helicobacter pylori,
pubmed-meshheading:18644389-Humans,
pubmed-meshheading:18644389-Japan,
pubmed-meshheading:18644389-Male,
pubmed-meshheading:18644389-Middle Aged,
pubmed-meshheading:18644389-P-Glycoprotein,
pubmed-meshheading:18644389-Peptic Ulcer,
pubmed-meshheading:18644389-Polymorphism, Single Nucleotide,
pubmed-meshheading:18644389-Risk Factors,
pubmed-meshheading:18644389-Stomach Neoplasms
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pubmed:year |
2008
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pubmed:articleTitle |
MDR1 C3435T polymorphism has no influence on developing Helicobacter pylori infection-related gastric cancer and peptic ulcer in Japanese.
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pubmed:affiliation |
First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan. sugimoto@bcm.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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