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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0024432,
umls-concept:C0085295,
umls-concept:C0086418,
umls-concept:C0205147,
umls-concept:C0332461,
umls-concept:C0443343,
umls-concept:C0741968,
umls-concept:C0851285,
umls-concept:C1171362,
umls-concept:C1334043,
umls-concept:C1515670,
umls-concept:C1533691
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pubmed:issue |
3
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pubmed:dateCreated |
2009-1-2
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pubmed:abstractText |
Mammalian orthologues of the Drosophila tribbles protein (Trb1, Trb2 and Trb3) are a recently described family of signalling molecules that regulate gene expression by modulation of protein kinase signalling pathways. In the present study, a screen for mRNA species specifically regulated in vulnerable regions of human atherosclerotic plaque demonstrated the up-regulation of both Trb1 and Trb2, the latter by more than 8-fold. In vitro experiments in primary human monocyte-derived macrophages showed that Trb2 expression was up-regulated by treatment with oxidized LDL (low-density lipoprotein), and that expression of recombinant Trb2 specifically reduced macrophage levels of IL-10 (interleukin-10) mRNA. Our results thus identify Trb2 as a highly regulated gene in vulnerable atherosclerotic lesions, and demonstrate inhibition of macrophage IL-10 biosynthesis as a potential pro-inflammatory consequence of high Trb2 expression, which may contribute to plaque instability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TRIB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TRIB2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/TRIB3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/oxidized low density lipoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1470-8736
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
241-8
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pubmed:meshHeading |
pubmed-meshheading:18643775-Antigens, CD,
pubmed-meshheading:18643775-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:18643775-Carotid Artery Diseases,
pubmed-meshheading:18643775-Cell Cycle Proteins,
pubmed-meshheading:18643775-Cells, Cultured,
pubmed-meshheading:18643775-Endarterectomy, Carotid,
pubmed-meshheading:18643775-Gene Expression Regulation,
pubmed-meshheading:18643775-Humans,
pubmed-meshheading:18643775-Interleukin-10,
pubmed-meshheading:18643775-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:18643775-Lipoproteins, LDL,
pubmed-meshheading:18643775-Macrophages,
pubmed-meshheading:18643775-Protein-Serine-Threonine Kinases,
pubmed-meshheading:18643775-RNA, Messenger,
pubmed-meshheading:18643775-Repressor Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Human tribbles homologue 2 is expressed in unstable regions of carotid plaques and regulates macrophage IL-10 in vitro.
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pubmed:affiliation |
GlaxoSmithKline Clinical Unit, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge CB2 2GG, U.K.
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pubmed:publicationType |
Journal Article
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