Source:http://linkedlifedata.com/resource/pubmed/id/18643306
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6 Pt 1
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pubmed:dateCreated |
2008-7-22
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pubmed:abstractText |
Meiosis is the specialized cell division required in sexual reproduction. During its early stages, in the mother cell nucleus, homologous chromosomes recognize each other and colocalize in a crucial step that remains one of the most mysterious of meiosis. Starting from recent discoveries on the system molecular components and interactions, we discuss a statistical mechanics model of chromosome early pairing. Binding molecules mediate long-distance interaction of special DNA recognition sequences and, if their concentration exceeds a critical threshold, they induce a spontaneous colocalization transition of chromosomes, otherwise independently diffusing.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1539-3755
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
061913
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pubmed:meshHeading |
pubmed-meshheading:18643306-Animals,
pubmed-meshheading:18643306-Biophysics,
pubmed-meshheading:18643306-Caenorhabditis elegans,
pubmed-meshheading:18643306-Chromosome Pairing,
pubmed-meshheading:18643306-Chromosomes,
pubmed-meshheading:18643306-DNA,
pubmed-meshheading:18643306-DNA Damage,
pubmed-meshheading:18643306-Drosophila,
pubmed-meshheading:18643306-Humans,
pubmed-meshheading:18643306-Kinetics,
pubmed-meshheading:18643306-Meiosis,
pubmed-meshheading:18643306-Models, Biological,
pubmed-meshheading:18643306-Models, Statistical,
pubmed-meshheading:18643306-Models, Theoretical,
pubmed-meshheading:18643306-Thermodynamics
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pubmed:year |
2008
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pubmed:articleTitle |
The colocalization transition of homologous chromosomes at meiosis.
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pubmed:affiliation |
Department of Physics and Complexity Science, University of Warwick, Coventry, United Kingdom.
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pubmed:publicationType |
Journal Article
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