Linked Life Data

18643016

Source:http://linkedlifedata.com/resource/pubmed/id/18643016

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 1
pubmed:dateCreated
2008-7-22
pubmed:abstractText
KIF1A kinesins are single-headed motor proteins which move on cylindrical nanotubes called microtubules (MTs). A normal MT consists of 13 protofilaments on which the equispaced motor binding sites form a periodic array. The collective movement of the kinesins on a MT is, therefore, analogous to vehicular traffic on multilane highways where each protofilament is the analog of a single lane. Does lane changing increase or decrease the motor flux per lane? We address this fundamental question here by appropriately extending a recent model [P. Greulich, Phys. Rev. E 75, 041905 (2007)]. By carrying out analytical calculations and computer simulations of this extended model, we predict that the flux per lane can increase or decrease with the increasing rate of lane changing, depending on the concentrations of motors and the rate of hydrolysis of ATP, the "fuel" molecules. Our predictions can be tested, in principle, by carrying out in vitro experiments with fluorescently labeled KIF1A molecules.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1539-3755
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
050902
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Traffic of single-headed motor proteins KIF1A: effects of lane changing.
pubmed:affiliation
Department of Physics, Indian Institute of Technology, Kanpur 208016, India. debch@iitk.ac.in
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't