Linked Life Data

18640093

Source:http://linkedlifedata.com/resource/pubmed/id/18640093

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-8-8
pubmed:abstractText
Androgen and androgen receptor (AR) play important roles in the formation and the progression of prostate cancer. AR activates its target genes by recruiting various coregulators and transcriptional factors. Here we show that the FOXP1 forkhead transcription factor is a novel androgen-regulated gene. By sequencing DNA fragments obtained from chromatin immunoprecipitation (ChIP), a bona-fide AR binding site (ARBS) is identified in an intron region of FOXP1 gene. FOXP1 can be induced by androgen in hormone-sensitive prostate cancer LNCaP cells at both mRNA and protein levels. In particular, a smaller FOXP1 variant, FOXP1D, is upregulated in response to androgen. Notably, we demonstrate that FOXP1 directly interacts with AR and negatively regulates AR signaling ligand-dependently, as exemplified by the transcriptional repression of PSA gene regulated by androgen-dependent FOXP1 recruitment on its enhancer region. We show that several other forkhead transcription factors are also androgen-responsive in LNCaP cells. Our study provides a new insight to the function of forkhead transcription factors that modulates AR signaling as an androgen-regulated transcriptional factor, which would contribute to the tumorigenesis of prostate cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1090-2104
pubmed:author
pubmed:issnType
Electronic
pubmed:day
19
pubmed:volume
374
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
388-93
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:18640093-Androgens, pubmed-meshheading:18640093-Binding Sites, pubmed-meshheading:18640093-Cell Line, Tumor, pubmed-meshheading:18640093-Chromatin Immunoprecipitation, pubmed-meshheading:18640093-Forkhead Transcription Factors, pubmed-meshheading:18640093-Gene Expression Regulation, Neoplastic, pubmed-meshheading:18640093-Humans, pubmed-meshheading:18640093-Introns, pubmed-meshheading:18640093-Male, pubmed-meshheading:18640093-Prostate-Specific Antigen, pubmed-meshheading:18640093-Prostatic Neoplasms, pubmed-meshheading:18640093-RNA, Messenger, pubmed-meshheading:18640093-Receptors, Androgen, pubmed-meshheading:18640093-Repressor Proteins, pubmed-meshheading:18640093-Signal Transduction, pubmed-meshheading:18640093-Transcription, Genetic, pubmed-meshheading:18640093-Transcriptional Activation
pubmed:year
2008
pubmed:articleTitle
FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells.
pubmed:affiliation
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't