Source:http://linkedlifedata.com/resource/pubmed/id/18639564
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2008-10-22
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pubmed:abstractText |
The serotonin-1A (5-HT1A) receptor serves as a hub to regulate the activity and actions of the serotonin system, and is expressed both as a presynaptic autoreceptor on raphe neurons, and as a major postsynaptic receptor in hippocampal, cortical, and hypothalamic regions involved in mood, emotion and stress response. As such, the level of expression of 5-HT1A receptors is implicated in the development of anxiety and depression phenotypes. This review focuses on the C(-1019)G (rs6295) promoter polymorphism of the 5-HT1A receptor gene (HTR1A) and its effect on the activity of transcription factors that recognize the C-allele, including Deaf-1, Hes1 and Hes5; its effects on 5-HT1A receptor expression in pre- and postsynaptic areas; as well as its implication in early postnatal development and adult neurogenesis in the hippocampus and cortex. Although several studies have now replicated the association of the G-allele with depression, panic disorder, neuroticism, and reduced response to antidepressant or antipsychotic treatment, ethnic, disease and genetic heterogeneity among subjects in different studies may obscure such associations. Gene-gene interaction studies suggest that the 5-HT1A receptor G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders. Finally, association of the G(-1019) allele with increased raphe 5-HT1A binding potential, increased amygdala reactivity to emotional stimuli, and reduced amygdala volume, particularly in disease states, suggests a functional role for the C(-1019)G site in 5-HT1A receptor dys-regulation and predisposition to mental illness.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0028-3908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
977-85
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pubmed:dateRevised |
2009-6-3
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pubmed:meshHeading |
pubmed-meshheading:18639564-Animals,
pubmed-meshheading:18639564-Antidepressive Agents,
pubmed-meshheading:18639564-Brain,
pubmed-meshheading:18639564-Gene Expression Regulation,
pubmed-meshheading:18639564-Genetic Predisposition to Disease,
pubmed-meshheading:18639564-Humans,
pubmed-meshheading:18639564-Mental Disorders,
pubmed-meshheading:18639564-Polymorphism, Genetic,
pubmed-meshheading:18639564-Receptor, Serotonin, 5-HT1A
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pubmed:year |
2008
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pubmed:articleTitle |
Transcriptional regulation at a HTR1A polymorphism associated with mental illness.
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pubmed:affiliation |
Ottawa Health Research Institute (Neuroscience), University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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