18638140

Source:http://linkedlifedata.com/resource/pubmed/id/18638140

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0018067, umls-concept:C0035820, umls-concept:C0078058, umls-concept:C0597298, umls-concept:C1256770, umls-concept:C1441414, umls-concept:C1553874, umls-concept:C1578820, umls-concept:C1621270
pubmed:dateCreated	2008-7-21
pubmed:abstractText	Many scientists have expended efforts to determine what regulates development of an indifferent gonad into either a testis or ovary. Expression of Sry and upregulation of Sox9 are factors that initiate formation of the testis-specific pathway to allow for both sex-specific vasculature and seminiferous cord formation. Migration of mesonephric precursors of peritubular myoid cells and endothelial cells into the differentiating testis is a critical step in formation of both of these structures. Furthermore, these events appear to be initiated downstream from Sry expression. Sertoli cell secretion of growth factors acts to attract these mesonephric cells. One hypothesis is that a growth factor specific for these cell linages act in concert to coordinate migration of both peritubular and endothelial cells. A second hypothesis is that several growth factors stimulate migration and differentiation of mesonephric 'stem-like' cells to result in migration and differentiation into several different cell lineages. While the specific mechanism is unclear, several growth factors have been implicated in the initiation of mesonephric cell migration. This review will focus on the proposed mechanisms of a growth factor, Vascular Endothelial Growth Factor, and how different angiogenic and inhibitory isoforms from this single gene may aid in development of testis-specific vascular development.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9015668
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/SOX9 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factors
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1439-0531
pubmed:author	pubmed-author:CULPM AMA, pubmed-author:CloptonD TDT, pubmed-author:CuppA SAS
pubmed:issnType	Electronic
pubmed:volume	43 Suppl 2
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	310-6
pubmed:dateRevised	2011-6-10
pubmed:meshHeading	pubmed-meshheading:18638140-Animals, pubmed-meshheading:18638140-Female, pubmed-meshheading:18638140-Gene Expression Regulation, Developmental, pubmed-meshheading:18638140-Gonads, pubmed-meshheading:18638140-Male, pubmed-meshheading:18638140-Mice, pubmed-meshheading:18638140-Models, Animal, pubmed-meshheading:18638140-SOX9 Transcription Factor, pubmed-meshheading:18638140-Sex Differentiation, pubmed-meshheading:18638140-Signal Transduction, pubmed-meshheading:18638140-Vascular Endothelial Growth Factors
pubmed:year	2008
pubmed:articleTitle	A proposed role for VEGF isoforms in sex-specific vasculature development in the gonad.
pubmed:affiliation	Animal Science Department, University of Nebraska-Lincoln, Lincoln, NE 68583-0908, USA.
pubmed:publicationType	Journal Article, Review, Research Support, N.I.H., Extramural