Source:http://linkedlifedata.com/resource/pubmed/id/18637658
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8-9
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pubmed:dateCreated |
2008-9-25
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pubmed:abstractText |
Solphos (7,7'-bis(diarylphosphino)-3,3',4,4'-tetrahydro-4,4'-dimethyl-8,8'-bis-2H-1,4-benzoxazine) is a new modular atropisomeric biaryl ligand with a very attractive activity profile. A technically feasible synthesis is described allowing the synthesis of various derivatives of enantiopure ligand on a technical scale. Very good catalytic performances have been demonstrated for the following transformations: Ru-catalyzed hydrogenation of various beta-keto esters (95-99 % ee, s/c up to 100,000), of acetyl acetone (>99 % ee, dl/meso>98:2), and of an exocyclic alpha,beta-unsaturated acid (98.6 % ee, s/c 250). In several cases, the nature of the PAr(2) moiety had a significant effect on the enantioselectivity. Furthermore, Rh and Ir Solphos complexes achieved high enantioselectivities for a novel synthesis of 3,3-disubstituted phthalides and the reductive coupling of alkynes with N-sulfonyl imines, respectively.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:status |
PubMed-not-MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1861-471X
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pubmed:author |
pubmed-author:BlaserHans-UlrichHU,
pubmed-author:KesselgruberMartinM,
pubmed-author:LotzMatthiasM,
pubmed-author:MüllerMarkusM,
pubmed-author:MartinPierreP,
pubmed-author:MeloneGianpietroG,
pubmed-author:NaudFrédéricF,
pubmed-author:PuginBenoîtB,
pubmed-author:SpindlerFelixF,
pubmed-author:ThommenMarcM,
pubmed-author:ZbindenPaulP
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1384-9
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pubmed:year |
2008
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pubmed:articleTitle |
Solphos: a new family of efficient biaryl diphosphine ligands.
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pubmed:affiliation |
Solvias AG, P.O. Box, 4002 Basel, Switzerland.
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pubmed:publicationType |
Journal Article
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