Linked Life Data

18637504

Source:http://linkedlifedata.com/resource/pubmed/id/18637504

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-7-21
pubmed:abstractText
The IE86 protein of human cytomegalovirus (HCMV) is unique among viral and cellular proteins because it negatively autoregulates its own expression, activates the viral early and late promoters, and both activates and inhibits cellular promoters. It promotes cell cycle progression from Go/G1 to G1/S and arrests cell cycle progression at the G1/S interface or at G2/M. The IE86 protein is essential because it creates a cellular environment favorable for viral replication. The multiple functions of the IE86 protein during the replication of HCMV are reviewed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0070-217X
pubmed:author
pubmed:issnType
Print
pubmed:volume
325
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-52
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Functional roles of the human cytomegalovirus essential IE86 protein.
pubmed:affiliation
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA. mark-stinski@uiowa.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural