|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2008-10-15
|
|
pubmed:abstractText |
Angioimmunoblastic T-cell lymphoma (AILT) and peripheral T-cell lymphoma, unspecified (PTCL-u) are relatively frequent subtypes of T- or natural killer cell lymphoma. To characterize the structural anomalies of chromosomes associated with these disorders, we here determined chromosome copy number alterations (CNAs) and loss of heterozygosity (LOH) at >55,000 single nucleotide polymorphism loci for clinical specimens of AILT (n=40) or PTCL-u (n=33). Recurrent copy number gain common to both conditions was detected on chromosomes 8, 9 and 19, whereas common LOH was most frequent for a region of chromosome 2. AILT- or PTCL-u-specific CNAs or LOH were also identified at 21 regions, some spanning only a few hundred base pairs. We also identified prognosis-related CNAs or LOH by several approaches, including Cox's proportional hazard analysis. Among the genes that mapped to such loci, a poor prognosis was linked to overexpression of CARMA1 at 7p22 and of MYCBP2 at 13q22, with both genes being localized within regions of frequent copy number gain. For a frequent LOH region at 2q34, we also identified IKAROS family zinc-finger 2 cDNAs encoding truncated proteins. Our data indicate that AILT and PTCL-u consist of heterogeneous subgroups with distinct transforming genetic alterations.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CARD Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CARD11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/IKZF2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ikaros Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/MYCBP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1476-5551
|
|
pubmed:author |
pubmed-author:AbeMM,
pubmed-author:ChoeY HYH,
pubmed-author:EnomotoMM,
pubmed-author:FujiwaraS-iSI,
pubmed-author:HatanakaHH,
pubmed-author:KurashinaKK,
pubmed-author:MannII,
pubmed-author:NakamuraNN,
pubmed-author:OzawaKK,
pubmed-author:SodaMM,
pubmed-author:TakadaSS,
pubmed-author:UenoTT,
pubmed-author:WatanabeHH,
pubmed-author:YamashitaYY
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1891-8
|
|
pubmed:meshHeading |
pubmed-meshheading:18633432-Adult,
pubmed-meshheading:18633432-Aged,
pubmed-meshheading:18633432-Aged, 80 and over,
pubmed-meshheading:18633432-CARD Signaling Adaptor Proteins,
pubmed-meshheading:18633432-Chromosome Aberrations,
pubmed-meshheading:18633432-DNA-Binding Proteins,
pubmed-meshheading:18633432-Female,
pubmed-meshheading:18633432-Guanylate Cyclase,
pubmed-meshheading:18633432-Humans,
pubmed-meshheading:18633432-Ikaros Transcription Factor,
pubmed-meshheading:18633432-Loss of Heterozygosity,
pubmed-meshheading:18633432-Lymphoma, T-Cell,
pubmed-meshheading:18633432-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:18633432-Male,
pubmed-meshheading:18633432-Middle Aged,
pubmed-meshheading:18633432-Neprilysin,
pubmed-meshheading:18633432-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18633432-Polymorphism, Single Nucleotide,
pubmed-meshheading:18633432-Prognosis,
pubmed-meshheading:18633432-Transcription Factors
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
High-resolution analysis of chromosome copy number alterations in angioimmunoblastic T-cell lymphoma and peripheral T-cell lymphoma, unspecified, with single nucleotide polymorphism-typing microarrays.
|
|
pubmed:affiliation |
Division of Functional Genomics, Jichi Medical University, Tochigi, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
